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COQ-10 Advanced

COQ-10 Advanced

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The body uses two forms of CoQ10. Ubiquinone, also known as the oxidized form, is better known and is used primarily for energy production in the electron transport energy cycle inside the cell. Ubiquinol plays a primary role in decreasing oxidative damage caused by lipid peroxidation within mitochondria. According to research, plasma ubiquinol is decreased in patients with hyperlipidemia. There is evidence that suggests that the ability to convert ubiquinone to ubiquinol may diminish with age, resulting in diminished protection against oxidative stress and reduced energy levels. CoQ 10 (ubiquinol) may provide a strong initial stage defense against cellular oxidative damage and requires supplementing to maintain optimum health. Researchers at East Texas Medical Center found that patients with advanced congestive heart failure taking high doses of ubiquinone CoQ10 were not able to achieve adequate improvements in blood serum CoQ10 levels. However, when switched to ubiquinol, blood CoQ10 levels improved dramatically with a consequential improvement in clinical symptoms and left ventricular function. CoQ10 is also being studied for its effects on TNF alpha, and therefore on inflammation.

CoQ-10 Advanced offers highly bioavailable ubiquinone coenzyme Q10 (CoQ10) in easy to swallow softgels. It is manufactured via a new, proprietary emulsification process that uses all-natural ingredients, including vitamin E, medium chain triglycerides (MCT) and lecithin, and is free of polysorbates, castor oil, and polyoxyethylated chemicals. Superior bioavailability has been demonstrated in an in-house human clinical trial, showing this material to be up to 390% more bioavailable than our previous, superior absorption, Q-Avail formulation.

Coenzyme Q10
Coenzyme Q10 is a fat-soluble, high molecular weight compound produced by the body for the basic functioning of cells. It is synthesized endogenously on a branch of the mevalonate pathway, which also produces cholesterol. CoQ10 plays a central role in cellular energy metabolism that produces adenosine triphosphate (ATP), the energy currency for muscle contraction and other cellular processes. Organs with high energy demands, such as the heart and liver, have the highest concentrations of CoQ10.

CoQ10 is recognized for its significant role in the electron transport chain as well as being one of the body’s most vital antioxidants. It is found in the mitochondria, the energy-producing center or “powerhouse” of the cell. In addition to being produced in the body, CoQ10 can also be obtained in small amounts through certain dietary sources, such as fish (salmon and tuna) and organ meats (heart, liver and kidney).These amounts (internal and dietary), however, may often be inadequate to meet the body’s demands. Additionally, age and various illnesses,
as well as the use of various medical classes, increase the need for this valuable nutrient. Thus, as is the case with many vitamins and minerals, supplemental amounts of CoQ10 may be beneficial for ameliorating specific health conditions and helping to prevent or limit oxidative damage.

CoQ10 Demystified
CoQ10 exists in both ubiquinone and ubiquinol forms, its names derived from the word “ubiquitous” because it is present everywhere in the human body. The number ten in “CoQ10” refers to its biochemical structure, which consists of ten isoprene units attached to a benzoquinone “head.”

In the mitochondrial electron transport system, CoQ10 undergoes continuous reversible oxidation and reduction. It is converted to ubiquinol (reduced form) when it accepts electrons and to ubiquinone (oxidized form) when it donates electrons. As an antioxidant, CoQ10 regulates membrane fluidity, recycles radical forms of vitamin C and E, and protects membrane phospholipids against peroxidation (the process whereby free radicals “steal” electrons from the lipids in cell membranes, which can result in cell damage).

Why is CoQ10 Important?
Low levels of ubiquinone have been documented in people experiencing various conditions including:
CoQ-10 Advanced
MICRO-EMULSIFED COQ10 IN 100 MG SOFTGEL
• Chronic fatigue syndrome4
• Congestive heart failure5
• Angina pectoris5
• Coronary artery disease5
• Cardiomyopathy6
• Chronic obstructive pulmonary disease7
• Parkinson’s disease8
• Cancer9
• Periodontal disease10
• Asthma11
• Age-related macular degeneration12
• Hyperthyroidism13
• HIV/AIDS14
• Cerebellar ataxia1

Who May Benefit
Supplementation with CoQ10 has been shown to provide a wide range of health benefits and may help support the following:
• Cardiovascular health
• Hypertension
• Aging
• Fatigue
• Dental health
• Eye health
• Renal health
• Migraines
• Neural and brain health
• Chemotherapy
• Genetic CoQ10 deficiencies
• Male infertility

  • Promotes energy production in the electron transport
  • Decreases oxidative damage caused by lipid peroxidation
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